Camptothecin
Camptothecin is a quinoline-based alkaloid found in the barks of the chinese camptotheca tree and the Asian nothapodytes tree.
Features
CAS No. 7689-03-4
Specification: 98%,99% Camptothecin
Test method: HPLC
Appearance: Light yellow crystal powder
Source: Camptotheca Acuminata Decne's leaf
Grade: Pharmaceutical and food
Basic Information
Product name: Camptothecin
CAS No. 7689-03-4
Molecular formula: C20H16N2O4
Molecular weight: 348.36
Specification: 98%,99% Camptothecin
Test method: HPLC
Appearance: Light yellow crystal powder
Source: Camptotheca Acuminata Decne's leaf
Grade: Pharmaceutical and food
Function
1. Camptothecin and its derivatives are unique in their ability to inhibit DNA Topoisomerase I, by stabilizing a covalent reaction intermediate termed the cleavable complex which ultimately causes tumor cell death.
2. In clinical it is widely believed that camptothecin analogs exhibited remarkable anti-tumour and anti-leukaemia activity. Topoisomerase is a basilic enzyme in the process of DNA replication, it is responsible for the winding / unwinding of the supercoiled DNA composing the chromosomes. If the chromosomes cannot be unwound, transcription of DNA message cannot occur and the protein cannot be synthesized, it ultimately causes cell death.
3. Application of camptothecin in clinic is limited due to serious side effects and poor water-solubility.
4. At present, some camptothecin analogs,either semi-synthetic or synthetic drug based on camptothecin, have been applied cancerous therapy such as while others have been obtained satisfying curative effects in clinic.
Application
1.It is mainly used in pharmaceutical field;
2.It is mainly used in health product industry.
3.Medicine and health products and food additives.
Specifications Sheet
| Analysis | Specification | Results |
| Assay(Camptothecin ) | ≥98.0% | 98.43% |
| Physical & Chemical Control | ||
| Identification | Positive | Complies |
| Appearance | White Powder | Complies |
| Odor | Characteristic | Complies |
| Mesh Size | 80 mesh | Complies |
| Loss On Drying | ≤5.0% | 2.27% |
| Methanol | ≤5.0% | 0.024% |
| Ethanol | ≤5.0% | 0.150% |
| Residue on Ignition | ≤3.0% | 1.05% |
| Heavy Metal Testing | ||
| Heavy Metals | ＜20ppm | Complies |
| As | ＜2ppm | Complies |
| LEAD(Pb) | < 0.5PPM | 0.22 ppm |
| MERCURY(Hg) | Not dectect | Complies |
| CADMIUM | < 1 PPM | 0.25 ppm |
| COPPER | < 1 PPM | 0.32 ppm |
| ARSENIC | < 1 PPM | 0.11 ppm |
| Microbiological | ||
| Total Plate Count | <1000/gMax | Complies |
| Staphylococcus Aurenus | Not Detected | Negative |
| Pseudomonas | Not Detected | Negative |
| Yeast & Mold | <100/gMax | Complies |
| Salmonella | Negative | Negative |
| E. Coli | Negative | Negative |
Shipping & Storage
Delivery:Sea/Air Shipping & International Express
Shipping Time: 2-3 working days after payment
Package: 1-5kg/Aluminum foil bag, size: 22cm (Width)*32cm (Length)
15-25kg/Drum, size: 38cm (Diameter)*50cm (Height)
Storage: Kept away from strong light and heat.
Shelf Life: 24 months
Quality&Certifications
